Assay Detail
Binding
CHEMBL5384082
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Binding affinity to alpha4beta7 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in mucosal vascular add-ressin cell adhesion molecule 1 coated wells by fluorescence based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.26 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408335 | — | — | 1 | 7.64 |
| CHEMBL5410616 | — | — | 1 | 7.39 |
| CHEMBL5395825 | — | — | 1 | 6.74 |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL5419935 | — | — | 1 | - |
| CHEMBL5417237 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL5437666 | — | — | 1 | - |
| CHEMBL5397743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408335 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL5410616 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5395825 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL88478 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5419935 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5417237 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4589062 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5437666 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5397743 | — | IC50 | > | 5000.0 | nM | - |