Assay Detail
Binding
CHEMBL5384083
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Binding affinity to alphaMbeta2 integrin receptor (unknown origin) preincubated for 30 mins followed by 30 mins incubation in fibrinogen coated wells by fluorescence based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.97 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417237 | — | — | 1 | 7.33 |
| CHEMBL5419935 | — | — | 1 | 6.61 |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL5410616 | — | — | 1 | - |
| CHEMBL5408335 | — | — | 1 | - |
| CHEMBL5395825 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL5437666 | — | — | 1 | - |
| CHEMBL5397743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417237 | — | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL5419935 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL88478 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5410616 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5408335 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5395825 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4589062 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5437666 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5397743 | — | IC50 | > | 5000.0 | nM | - |