Assay Detail
Functional
CHEMBL5384527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type Zaire EBOV Mayinga infected in Vero E6 cells incubated for 3 days by immunofocus assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Zaire ebolavirus |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
<i>N</i>'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.95 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426718 | — | — | 1 | 6.60 |
| CHEMBL5414982 | — | — | 1 | 6.52 |
| CHEMBL5398314 | — | — | 1 | 6.28 |
| CHEMBL5172194 | — | — | 1 | 5.82 |
| CHEMBL5424177 | — | — | 1 | 5.72 |
| CHEMBL5433897 | — | — | 1 | 5.57 |
| CHEMBL5428579 | — | — | 1 | 5.11 |
| CHEMBL5395997 | — | — | 1 | - |
| CHEMBL1616834 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426718 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5414982 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5398314 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5172194 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5424177 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5433897 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5428579 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5395997 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1616834 | — | EC50 | > | 100000.0 | nM | - |