Assay Detail
Functional
CHEMBL5384759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 10 days and replacement with fresh media with compounds on day 5 by CTG assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.73 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434183 | — | — | 1 | 8.62 |
| CHEMBL5409410 | — | — | 1 | 8.32 |
| CHEMBL5411825 | — | — | 1 | 8.21 |
| CHEMBL5416117 | — | — | 1 | 8.12 |
| CHEMBL5414359 | — | — | 1 | 8.07 |
| CHEMBL5416758 | — | — | 1 | 7.93 |
| CHEMBL5396725 | — | — | 1 | 7.93 |
| CHEMBL5425043 | — | — | 1 | 7.61 |
| CHEMBL5440319 | — | — | 1 | 7.14 |
| CHEMBL4225966 | SEL-120 FREE BASE | 1.0 | 1 | 6.60 |
| CHEMBL5427899 | — | — | 1 | 6.43 |
| CHEMBL5417604 | — | — | 1 | - |
| CHEMBL5432423 | — | — | 1 | - |
| CHEMBL5397969 | — | — | 1 | - |
| CHEMBL5429467 | — | — | 1 | - |
| CHEMBL5406025 | — | — | 1 | - |
| CHEMBL5436530 | — | — | 1 | - |
| CHEMBL5402190 | — | — | 1 | - |
| CHEMBL5423457 | — | — | 1 | - |
| CHEMBL5416134 | — | — | 1 | - |
| CHEMBL5412471 | — | — | 1 | - |
| CHEMBL5402477 | — | — | 1 | - |
| CHEMBL5435821 | — | — | 1 | - |
| CHEMBL5405004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434183 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5409410 | — | IC50 | = | 4.75 | nM | 8.32 |
| CHEMBL5411825 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5416117 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5414359 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5416758 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5396725 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5425043 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL5440319 | — | IC50 | = | 72.8 | nM | 7.14 |
| CHEMBL4225966 | SEL-120 FREE BASE | IC50 | = | 248.75 | nM | 6.60 |
| CHEMBL5427899 | — | IC50 | = | 367.3 | nM | 6.43 |
| CHEMBL5417604 | — | IC50 | - | — | - | |
| CHEMBL5432423 | — | IC50 | - | — | - | |
| CHEMBL5397969 | — | IC50 | - | — | - | |
| CHEMBL5429467 | — | IC50 | - | — | - | |
| CHEMBL5406025 | — | IC50 | - | — | - | |
| CHEMBL5436530 | — | IC50 | - | — | - | |
| CHEMBL5402190 | — | IC50 | - | — | - | |
| CHEMBL5423457 | — | IC50 | - | — | - | |
| CHEMBL5416134 | — | IC50 | - | — | - | |
| CHEMBL5412471 | — | IC50 | - | — | - | |
| CHEMBL5402477 | — | IC50 | - | — | - | |
| CHEMBL5435821 | — | IC50 | - | — | - | |
| CHEMBL5405004 | — | IC50 | - | — | - |