Assay Detail
Functional
CHEMBL5385068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human OX2R expressed in CHO-K1 cells assessed as increase in intracellular calcium
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.02 | 6.84 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434113 | — | — | 1 | 6.84 |
| CHEMBL5417451 | — | — | 1 | 6.78 |
| CHEMBL5423828 | — | — | 1 | 6.72 |
| CHEMBL5396114 | — | — | 1 | 6.64 |
| CHEMBL5410801 | — | — | 1 | 6.56 |
| CHEMBL5415350 | — | — | 1 | 6.53 |
| CHEMBL5407752 | — | — | 1 | 6.02 |
| CHEMBL5422867 | — | — | 1 | 5.99 |
| CHEMBL5411141 | — | — | 1 | 5.89 |
| CHEMBL5393867 | — | — | 1 | 5.78 |
| CHEMBL5406322 | — | — | 1 | 5.62 |
| CHEMBL5422351 | — | — | 1 | 5.48 |
| CHEMBL5410302 | — | — | 1 | 5.19 |
| CHEMBL5403398 | — | — | 1 | 5.15 |
| CHEMBL5394185 | — | — | 1 | 5.07 |
| CHEMBL5438232 | — | — | 1 | - |
| CHEMBL5403259 | — | — | 1 | - |
| CHEMBL5405864 | — | — | 1 | - |
| CHEMBL5428873 | — | — | 1 | - |
| CHEMBL5406525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434113 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5417451 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5423828 | — | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL5396114 | — | EC50 | = | 229.0 | nM | 6.64 |
| CHEMBL5410801 | — | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL5415350 | — | EC50 | = | 295.0 | nM | 6.53 |
| CHEMBL5407752 | — | EC50 | = | 955.0 | nM | 6.02 |
| CHEMBL5422867 | — | EC50 | = | 1015.0 | nM | 5.99 |
| CHEMBL5411141 | — | EC50 | = | 1289.0 | nM | 5.89 |
| CHEMBL5393867 | — | EC50 | = | 1661.0 | nM | 5.78 |
| CHEMBL5406322 | — | EC50 | = | 2411.0 | nM | 5.62 |
| CHEMBL5422351 | — | EC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL5410302 | — | EC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL5403398 | — | EC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL5394185 | — | EC50 | = | 8551.0 | nM | 5.07 |
| CHEMBL5438232 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5403259 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5405864 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5428873 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5406525 | — | Activity | - | — | - |