Assay Detail
Binding
CHEMBL5385182
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Inhibition of HDAC in human HeLa cells nuclear extract incubated for 30 mins by multiplate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.64 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5433552 | — | — | 1 | 9.77 |
| CHEMBL5395502 | — | — | 1 | 9.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 9.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5433552 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5395502 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 0.35 | nM | 9.46 |