Assay Detail
Functional
CHEMBL5385190
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Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK-8 assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.73 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5433552 | — | — | 1 | 6.14 |
| CHEMBL5395502 | — | — | 1 | 5.90 |
| CHEMBL5432341 | — | — | 1 | 5.84 |
| CHEMBL5437969 | — | — | 1 | 5.83 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 5.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.75 |
| CHEMBL5440597 | — | — | 1 | 5.69 |
| CHEMBL5409823 | — | — | 1 | 5.67 |
| CHEMBL5424724 | — | — | 1 | 5.65 |
| CHEMBL5427399 | — | — | 1 | 5.63 |
| CHEMBL5418300 | — | — | 1 | 5.54 |
| CHEMBL5403924 | — | — | 1 | 5.53 |
| CHEMBL5427372 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5433552 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5395502 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5432341 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5437969 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5440597 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5409823 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5424724 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL5427399 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5418300 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL5403924 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5427372 | — | IC50 | = | 3080.0 | nM | 5.51 |