Assay Detail
Binding
CHEMBL5385329
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Inhibition of recombinant Anopheles gambiae AchE1 using acetylthiocholine iodide as substrate by spectrophotometric Ellman's method
31
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.18 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419436 | — | — | 1 | 6.19 |
| CHEMBL5440621 | — | — | 2 | 6.10 |
| CHEMBL1202939 | — | — | 2 | 6.10 |
| CHEMBL5421973 | — | — | 2 | 6.00 |
| CHEMBL5415881 | — | — | 1 | 5.64 |
| CHEMBL5419417 | — | — | 1 | 5.60 |
| CHEMBL5427383 | — | — | 1 | 5.52 |
| CHEMBL5401085 | — | — | 2 | 5.44 |
| CHEMBL5416845 | — | — | 2 | 5.40 |
| CHEMBL5401005 | — | — | 1 | 5.38 |
| CHEMBL5403260 | — | — | 2 | 5.10 |
| CHEMBL1202933 | — | — | 1 | 4.85 |
| CHEMBL5397966 | — | — | 1 | 4.80 |
| CHEMBL5413217 | — | — | 1 | 4.72 |
| CHEMBL5404393 | — | — | 2 | 4.64 |
| CHEMBL5409029 | — | — | 1 | 4.60 |
| CHEMBL5424185 | — | — | 2 | 4.43 |
| CHEMBL5404712 | — | — | 1 | 4.35 |
| CHEMBL1202929 | — | — | 1 | 4.28 |
| CHEMBL5405571 | — | — | 1 | 4.14 |
| CHEMBL1202941 | — | — | 1 | 4.07 |
| CHEMBL5409526 | — | — | 1 | - |
| CHEMBL1202930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419436 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1202939 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5440621 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL1202939 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5440621 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5421973 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5421973 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5415881 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5419417 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5427383 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5401085 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5401085 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL5416845 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL5401005 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5416845 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5403260 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5403260 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1202933 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5397966 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5413217 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5404393 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5409029 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5404393 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL5424185 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5424185 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL5404712 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1202929 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5405571 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1202941 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL5409526 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL1202930 | — | IC50 | = | 146000.0 | nM | - |