Assay Detail
Binding
CHEMBL5385334
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Binding affinity to recombinant Anopheles gambiae AchE1 G122S mutant assessed as inhibition constant using acetylthiocholine iodide as substrate by spectrophotometric Ellman's method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Anopheles gambiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.50 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421973 | — | — | 1 | 4.72 |
| CHEMBL5403260 | — | — | 1 | 4.27 |
| CHEMBL1202939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421973 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL5403260 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL1202939 | — | Ki | - | — | - |