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Assay Detail

CHEMBL5385486

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant DHODH by colorimetric assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications.
Vietor J, Gege C, Stiller T, Busch R, Schallmayer E, Kohlhof H, Höfner G, Pabel J, Marschner JA, Merk D.
J Med Chem (2023) 66 : 6391 -6402
PubMed 37127285 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.33 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5408943 1 7.89
CHEMBL5396308 1 7.66
CHEMBL5429444 1 7.30
CHEMBL5406415 1 7.28
CHEMBL5417026 1 7.19
CHEMBL5439713 1 6.82
CHEMBL5398990 1 6.70
CHEMBL5432354 1 6.57
CHEMBL5415127 1 6.52
CHEMBL5437165 1 6.51
CHEMBL5408286 1 6.43
CHEMBL5394449 1 6.42
CHEMBL5405308 1 6.40
CHEMBL5427377 1 6.22
CHEMBL197194 VIDOFLUDIMUS 3.0 1 6.21
CHEMBL5431965 1 6.19
CHEMBL5402885 1 6.14
CHEMBL5395588 1 6.05
CHEMBL5408707 1 6.02
CHEMBL5404750 1 5.93
CHEMBL5426306 1 5.77
CHEMBL5417085 1 5.77
CHEMBL5420122 1 5.70
CHEMBL5409772 1 5.43
CHEMBL5433526 1 5.11
CHEMBL5439642 1 4.29
CHEMBL5404933 1 -
CHEMBL5401382 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5408943 IC50 = 13.0 nM 7.89
CHEMBL5396308 IC50 = 22.0 nM 7.66
CHEMBL5429444 IC50 = 50.0 nM 7.30
CHEMBL5406415 IC50 = 53.0 nM 7.28
CHEMBL5417026 IC50 = 64.0 nM 7.19
CHEMBL5439713 IC50 = 150.0 nM 6.82
CHEMBL5398990 IC50 = 200.0 nM 6.70
CHEMBL5432354 IC50 = 270.0 nM 6.57
CHEMBL5415127 IC50 = 300.0 nM 6.52
CHEMBL5437165 IC50 = 310.0 nM 6.51
CHEMBL5408286 IC50 = 370.0 nM 6.43
CHEMBL5394449 IC50 = 380.0 nM 6.42
CHEMBL5405308 IC50 = 400.0 nM 6.40
CHEMBL5427377 IC50 = 600.0 nM 6.22
CHEMBL197194 VIDOFLUDIMUS IC50 = 610.0 nM 6.21
CHEMBL5431965 IC50 = 640.0 nM 6.19
CHEMBL5402885 IC50 = 720.0 nM 6.14
CHEMBL5395588 IC50 = 900.0 nM 6.05
CHEMBL5408707 IC50 = 960.0 nM 6.02
CHEMBL5404750 IC50 = 1180.0 nM 5.93
CHEMBL5426306 IC50 = 1700.0 nM 5.77
CHEMBL5417085 IC50 = 1700.0 nM 5.77
CHEMBL5420122 IC50 = 1980.0 nM 5.70
CHEMBL5409772 IC50 = 3700.0 nM 5.43
CHEMBL5433526 IC50 = 7700.0 nM 5.11
CHEMBL5439642 IC50 = 51000.0 nM 4.29
CHEMBL5404933 IC50 > 30000.0 nM -
CHEMBL5401382 IC50 > 50000.0 nM -