Assay Detail
Binding
CHEMBL5385754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to VHL (unknown origin) assessed as dissociation constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor (CHEMBL3108660) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A beginner's guide to current synthetic linker strategies towards VHL-recruiting PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.05 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225470 | — | — | 1 | 7.36 |
| CHEMBL3344081 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225470 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL3344081 | — | Kd | = | 185.0 | nM | 6.73 |