Assay Detail
Functional
CHEMBL5386112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FFA1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a structurally novel, potent, and once-weekly free fatty acid receptor 1 agonist for the treatment of diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.31 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3915620 | LY2881835 | 1.0 | 1 | 8.05 |
| CHEMBL4794409 | — | — | 1 | 7.92 |
| CHEMBL1829173 | — | — | 1 | 7.89 |
| CHEMBL1829174 | FASIGLIFAM | 3.0 | 1 | 7.85 |
| CHEMBL4579901 | — | — | 1 | 7.17 |
| CHEMBL277522 | FENBUFEN | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3915620 | LY2881835 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4794409 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1829173 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1829174 | FASIGLIFAM | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4579901 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL277522 | FENBUFEN | EC50 | = | 10000.0 | nM | 5.00 |