Assay Detail
Binding
CHEMBL5386789
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Inhibition of JNK1 (unknown origin) incubated for 20 mins in presence of 33P-ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.14 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423620 | — | — | 1 | 7.84 |
| CHEMBL5436023 | — | — | 1 | 7.49 |
| CHEMBL5401511 | — | — | 1 | 7.25 |
| CHEMBL5424946 | — | — | 1 | 7.12 |
| CHEMBL5403678 | — | — | 1 | 7.08 |
| CHEMBL5411160 | — | — | 1 | 7.08 |
| CHEMBL5408675 | — | — | 1 | 7.06 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.93 |
| CHEMBL5429577 | — | — | 1 | 6.80 |
| CHEMBL5398642 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423620 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5436023 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL5401511 | — | IC50 | = | 56.1 | nM | 7.25 |
| CHEMBL5424946 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL5403678 | — | IC50 | = | 82.7 | nM | 7.08 |
| CHEMBL5411160 | — | IC50 | = | 82.8 | nM | 7.08 |
| CHEMBL5408675 | — | IC50 | = | 86.5 | nM | 7.06 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 117.4 | nM | 6.93 |
| CHEMBL5429577 | — | IC50 | = | 158.1 | nM | 6.80 |
| CHEMBL5398642 | — | IC50 | = | 160.2 | nM | 6.79 |