Assay Detail
Binding
CHEMBL5386790
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Inhibition of GSK3beta (unknown origin) incubated for 20 mins in presence of 33P-ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.14 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.39 |
| CHEMBL5411160 | — | — | 1 | 6.71 |
| CHEMBL5398642 | — | — | 1 | 6.33 |
| CHEMBL5401511 | — | — | 1 | 5.90 |
| CHEMBL5424946 | — | — | 1 | 5.78 |
| CHEMBL5423620 | — | — | 1 | 5.75 |
| CHEMBL5436023 | — | — | 1 | 5.65 |
| CHEMBL5403678 | — | — | 1 | 5.41 |
| CHEMBL5429577 | — | — | 1 | 5.31 |
| CHEMBL5408675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4.106 | nM | 8.39 |
| CHEMBL5411160 | — | IC50 | = | 194.8 | nM | 6.71 |
| CHEMBL5398642 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5401511 | — | IC50 | = | 1249.5 | nM | 5.90 |
| CHEMBL5424946 | — | IC50 | = | 1659.7 | nM | 5.78 |
| CHEMBL5423620 | — | IC50 | = | 1800.1 | nM | 5.75 |
| CHEMBL5436023 | — | IC50 | = | 2248.0 | nM | 5.65 |
| CHEMBL5403678 | — | IC50 | = | 3889.7 | nM | 5.41 |
| CHEMBL5429577 | — | IC50 | = | 4861.0 | nM | 5.31 |
| CHEMBL5408675 | — | IC50 | > | 10000.0 | nM | - |