Assay Detail

CHEMBL5387410

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant in presence of NADH, DD-CoA by spectrophotometry based analysis

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL1849) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL1849) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Enoyl-[acyl-carrier-protein] reductase [NADH]

CHEMBL1849

Anchored from Assay target.

Protein identity Enoyl-[acyl-carrier-protein] reductase [NADH]

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mycobacterium tuberculosis
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL1849) ↗

Type	SINGLE PROTEIN
Organism	Mycobacterium tuberculosis

Publication

Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.

Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA.
Eur J Med Chem (2023) 245 : 114908 -114908
PubMed 36435016 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.12	9.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL64	ISONIAZID	4.0	1	9.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL64	ISONIAZID	Ki	=	0.75	nM	9.12