Assay Detail
Functional
CHEMBL5387597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human S1PR1 expressed in HeLa cells coexpressing Galpha16 assessed as reduction in AUY954 induced calcium mobilization preincubated for 20 mins followed by AUY954 addition by FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086703 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086703 | — | IC50 | = | 2.5 | nM | 8.60 |