Assay Detail
Functional
CHEMBL5387598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human S1PR1 expressed in CHO cells assessed as reduction in S1P induced calcium mobilization preincubated for 15 mins followed by S1P addition and measured after 120 mins by GTPgammaS assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
S1PR1 modulators in multiple sclerosis: Efficacy, safety, comparison, and chemical structure insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086703 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086703 | — | IC50 | = | 2.0 | nM | 8.70 |