Assay Detail
Functional
CHEMBL5387600
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Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.14 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410213 | — | — | 1 | 6.36 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.10 |
| CHEMBL5396598 | — | — | 1 | 5.66 |
| CHEMBL154716 | — | — | 1 | 5.63 |
| CHEMBL3338596 | — | — | 1 | 5.54 |
| CHEMBL4161091 | — | — | 1 | 5.53 |
| CHEMBL4167901 | — | — | 1 | 5.25 |
| CHEMBL4875036 | — | — | 1 | 5.22 |
| CHEMBL1814483 | — | — | 1 | 5.15 |
| CHEMBL2297365 | — | — | 1 | 5.10 |
| CHEMBL5433720 | — | — | 1 | 5.08 |
| CHEMBL498193 | — | — | 1 | 4.84 |
| CHEMBL3105275 | — | — | 1 | 4.79 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.69 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.61 |
| CHEMBL515242 | — | — | 1 | 4.57 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | — | 1 | 4.30 |
| CHEMBL151757 | — | — | 1 | 4.10 |
| CHEMBL5395466 | — | — | 1 | - |
| CHEMBL151678 | — | — | 1 | - |
| CHEMBL5430565 | — | — | 1 | - |
| CHEMBL482410 | — | — | 1 | - |
| CHEMBL473575 | — | — | 1 | - |
| CHEMBL478482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410213 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5396598 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL154716 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL3338596 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL4161091 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4167901 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4875036 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL1814483 | — | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL2297365 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL5433720 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL498193 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL3105275 | — | IC50 | = | 16350.0 | nM | 4.79 |
| CHEMBL140 | CURCUMIN | IC50 | = | 20340.0 | nM | 4.69 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 24840.0 | nM | 4.61 |
| CHEMBL515242 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | IC50 | = | 50480.0 | nM | 4.30 |
| CHEMBL151757 | — | IC50 | = | 79750.0 | nM | 4.10 |
| CHEMBL5395466 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5430565 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL482410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL473575 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL478482 | — | IC50 | > | 100000.0 | nM | - |