Assay Detail
Functional
CHEMBL5387601
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.20 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161091 | — | — | 1 | 5.97 |
| CHEMBL4167901 | — | — | 1 | 5.93 |
| CHEMBL5396598 | — | — | 1 | 5.80 |
| CHEMBL1814483 | — | — | 1 | 5.70 |
| CHEMBL498193 | — | — | 1 | 5.53 |
| CHEMBL3338596 | — | — | 1 | 5.48 |
| CHEMBL4875036 | — | — | 1 | 5.40 |
| CHEMBL5410213 | — | — | 1 | 5.24 |
| CHEMBL5433720 | — | — | 1 | 5.17 |
| CHEMBL154716 | — | — | 1 | 5.13 |
| CHEMBL515242 | — | — | 1 | 4.95 |
| CHEMBL3105275 | — | — | 1 | 4.93 |
| CHEMBL2297365 | — | — | 1 | 4.84 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | — | 1 | 4.58 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.35 |
| CHEMBL151757 | — | — | 1 | 4.18 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL473575 | — | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
| CHEMBL5395466 | — | — | 1 | - |
| CHEMBL151678 | — | — | 1 | - |
| CHEMBL5430565 | — | — | 1 | - |
| CHEMBL482410 | — | — | 1 | - |
| CHEMBL478482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161091 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4167901 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5396598 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1814483 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL498193 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3338596 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4875036 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL5410213 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5433720 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL154716 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL515242 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL3105275 | — | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL2297365 | — | IC50 | = | 14340.0 | nM | 4.84 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | IC50 | = | 26310.0 | nM | 4.58 |
| CHEMBL140 | CURCUMIN | IC50 | = | 44750.0 | nM | 4.35 |
| CHEMBL151757 | — | IC50 | = | 66750.0 | nM | 4.18 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | - | — | - | |
| CHEMBL473575 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | - | — | - | |
| CHEMBL5395466 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5430565 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL482410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL478482 | — | IC50 | > | 100000.0 | nM | - |