Assay Detail
Functional
CHEMBL5387755
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Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in A549 cells assessed as reduction in cell cytopathic effect incubated with cells for 2 hrs prior to viral infection followed by MDCK cells addition at 24 hrs pi and measured after 72 hrs by Reed-Muench method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 9.00 |
| CHEMBL5397789 | — | — | 1 | 7.52 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 7.40 |
| CHEMBL5419341 | — | — | 1 | 7.30 |
| CHEMBL5429336 | — | — | 1 | 6.77 |
| CHEMBL5413081 | — | — | 1 | 5.94 |
| CHEMBL5433576 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5397789 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5419341 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5429336 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5413081 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5433576 | — | EC50 | = | 1450.0 | nM | 5.84 |