Assay Detail
Functional
CHEMBL5387809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 method
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.05 | 5.05 |
| IC20 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418688 | — | — | 2 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418688 | — | IC50 | = | 8883.0 | nM | 5.05 |
| CHEMBL5418688 | — | IC20 | = | 4.189 | uM | - |