Assay Detail
Functional
CHEMBL5387830
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Cytotoxicity against human LS180 cells assessed as cell inhibition measured after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS180 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417409 | — | — | 1 | 5.54 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.47 |
| CHEMBL5394210 | — | — | 1 | 5.36 |
| CHEMBL5436715 | — | — | 1 | 4.72 |
| CHEMBL5407504 | — | — | 1 | 4.70 |
| CHEMBL5427300 | — | — | 1 | 4.68 |
| CHEMBL5401928 | — | — | 1 | 4.59 |
| CHEMBL5437033 | — | — | 1 | 4.47 |
| CHEMBL403176 | EUDISTOMIN Y1 | — | 1 | 4.05 |
| CHEMBL1682916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417409 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5394210 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5436715 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5407504 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5427300 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL5401928 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL5437033 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL403176 | EUDISTOMIN Y1 | IC50 | = | 89800.0 | nM | 4.05 |
| CHEMBL1682916 | — | IC50 | = | 258500.0 | nM | - |