Assay Detail
Functional
CHEMBL5387918
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Cytotoxicity against human HT-29 cells incubated for 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Asiatic acid as a leading structure for derivatives combining sub-nanomolar cytotoxicity, high selectivity, and the ability to overcome drug resistance in human preclinical tumor models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.48 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422662 | — | — | 1 | 8.22 |
| CHEMBL4281011 | — | — | 1 | 7.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.05 |
| CHEMBL4280590 | — | — | 1 | 5.89 |
| CHEMBL5400445 | — | — | 1 | 5.87 |
| CHEMBL3785137 | — | — | 1 | 5.05 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | - |
| CHEMBL428971 | RHODAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422662 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4281011 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4280590 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5400445 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3785137 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL404313 | ASIATIC ACID | EC50 | > | 30000.0 | nM | - |
| CHEMBL428971 | RHODAMINE | EC50 | > | 30000.0 | nM | - |