Assay Detail
Binding
CHEMBL5387958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by ELISA method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.10 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.57 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.35 |
| CHEMBL5404379 | — | — | 1 | 7.31 |
| CHEMBL5430378 | — | — | 1 | 7.22 |
| CHEMBL5413403 | — | — | 1 | 7.22 |
| CHEMBL5424006 | — | — | 1 | 7.10 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.10 |
| CHEMBL5431270 | — | — | 1 | 7.05 |
| CHEMBL5403077 | — | — | 1 | 7.00 |
| CHEMBL5420858 | — | — | 1 | 6.89 |
| CHEMBL5396677 | — | — | 1 | 6.85 |
| CHEMBL5422492 | — | — | 1 | 6.82 |
| CHEMBL5408885 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122 | ROFECOXIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL118 | CELECOXIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5404379 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5430378 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5413403 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5424006 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5431270 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5403077 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5420858 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5396677 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5422492 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5408885 | — | IC50 | = | 156.0 | nM | 6.81 |