Assay Detail
Functional
CHEMBL5388347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CM-AS16 cells cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CM-AS16 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.07 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410723 | — | — | 1 | 5.68 |
| CHEMBL5400171 | — | — | 1 | 5.54 |
| CHEMBL5423005 | — | — | 1 | 5.51 |
| CHEMBL5406520 | — | — | 1 | 5.42 |
| CHEMBL5400608 | — | — | 1 | 5.40 |
| CHEMBL5405891 | — | — | 1 | 5.40 |
| CHEMBL5415370 | — | — | 1 | 5.38 |
| CHEMBL5413233 | — | — | 1 | 5.36 |
| CHEMBL5429075 | — | — | 1 | 5.34 |
| CHEMBL5408811 | — | — | 1 | 5.31 |
| CHEMBL5411573 | — | — | 1 | 5.31 |
| CHEMBL5438468 | — | — | 1 | 5.30 |
| CHEMBL5432952 | — | — | 1 | 5.28 |
| CHEMBL5405637 | — | — | 1 | 5.26 |
| CHEMBL5430385 | — | — | 1 | 5.25 |
| CHEMBL5432750 | — | — | 1 | 5.23 |
| CHEMBL5416438 | — | — | 1 | 5.22 |
| CHEMBL5436184 | — | — | 1 | 5.20 |
| CHEMBL5428451 | — | — | 1 | 5.17 |
| CHEMBL5400628 | — | — | 1 | 5.06 |
| CHEMBL5429437 | — | — | 1 | 5.05 |
| CHEMBL5425157 | — | — | 1 | 5.04 |
| CHEMBL5424985 | — | — | 1 | 5.00 |
| CHEMBL5416112 | — | — | 1 | 4.97 |
| CHEMBL5403104 | — | — | 1 | 4.97 |
| CHEMBL5432068 | — | — | 1 | 4.92 |
| CHEMBL5424654 | — | — | 1 | 4.86 |
| CHEMBL5430454 | — | — | 1 | 4.86 |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | 4.86 |
| CHEMBL5412542 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410723 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5400171 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5423005 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5406520 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5400608 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5405891 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5415370 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5413233 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5429075 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5408811 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5411573 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5438468 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5432952 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5405637 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5430385 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5432750 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5416438 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5436184 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5428451 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5400628 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5429437 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5425157 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5424985 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5416112 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5403104 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5432068 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5424654 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL5430454 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5412542 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5405668 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5406011 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL5439215 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5410356 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL5409557 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL420815 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL5429507 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL5402890 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL5409690 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL5424961 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5412378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5400004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490512 | — | IC50 | > | 100000.0 | nM | - |