Assay Detail
Functional
CHEMBL5388348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CRMM-2 cells cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CRMM-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.02 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436184 | — | — | 1 | 6.22 |
| CHEMBL5400171 | — | — | 1 | 6.16 |
| CHEMBL5408811 | — | — | 1 | 5.96 |
| CHEMBL5405637 | — | — | 1 | 5.89 |
| CHEMBL5432750 | — | — | 1 | 5.80 |
| CHEMBL5406520 | — | — | 1 | 5.51 |
| CHEMBL5410723 | — | — | 1 | 5.50 |
| CHEMBL5423005 | — | — | 1 | 5.43 |
| CHEMBL5405891 | — | — | 1 | 5.42 |
| CHEMBL5429075 | — | — | 1 | 5.40 |
| CHEMBL5415370 | — | — | 1 | 5.38 |
| CHEMBL5432952 | — | — | 1 | 5.38 |
| CHEMBL5438468 | — | — | 1 | 5.29 |
| CHEMBL5400628 | — | — | 1 | 5.23 |
| CHEMBL5425157 | — | — | 1 | 5.18 |
| CHEMBL5430385 | — | — | 1 | 5.18 |
| CHEMBL5428451 | — | — | 1 | 5.17 |
| CHEMBL5416112 | — | — | 1 | 5.12 |
| CHEMBL5432068 | — | — | 1 | 5.10 |
| CHEMBL5403104 | — | — | 1 | 5.09 |
| CHEMBL5413233 | — | — | 1 | 5.06 |
| CHEMBL5429437 | — | — | 1 | 5.03 |
| CHEMBL5400608 | — | — | 1 | 5.02 |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | 4.87 |
| CHEMBL420815 | — | — | 1 | 4.84 |
| CHEMBL5439215 | — | — | 1 | 4.83 |
| CHEMBL5412542 | — | — | 1 | 4.79 |
| CHEMBL5406011 | — | — | 1 | 4.76 |
| CHEMBL5416438 | — | — | 1 | 4.68 |
| CHEMBL5410356 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436184 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5400171 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5408811 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5405637 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5432750 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5406520 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5410723 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5423005 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5405891 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5429075 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5415370 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5432952 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5438468 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5400628 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5430385 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5425157 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5428451 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5416112 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5432068 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5403104 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5413233 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5429437 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5400608 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL420815 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL5439215 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL5412542 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL5406011 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5416438 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL5410356 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5405668 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL5411573 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL5402890 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL5430454 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL5441042 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL5409690 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL5424985 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL5429507 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL5427040 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL5409557 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL5430638 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL5421922 | — | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL5424654 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL5400004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490512 | — | IC50 | > | 100000.0 | nM | - |