Assay Detail
Toxicity
CHEMBL5388352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PIG1 cells cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | PIG1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 4.76 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436184 | — | — | 1 | 6.30 |
| CHEMBL5410723 | — | — | 1 | 5.77 |
| CHEMBL5405637 | — | — | 1 | 5.72 |
| CHEMBL5438468 | — | — | 1 | 5.40 |
| CHEMBL5423005 | — | — | 1 | 5.24 |
| CHEMBL5400628 | — | — | 1 | 5.17 |
| CHEMBL5432068 | — | — | 1 | 5.11 |
| CHEMBL5412542 | — | — | 1 | 5.10 |
| CHEMBL5430385 | — | — | 1 | 5.06 |
| CHEMBL5408811 | — | — | 1 | 5.04 |
| CHEMBL5432750 | — | — | 1 | 5.04 |
| CHEMBL5432952 | — | — | 1 | 4.98 |
| CHEMBL5406520 | — | — | 1 | 4.94 |
| CHEMBL5428451 | — | — | 1 | 4.87 |
| CHEMBL5441042 | — | — | 1 | 4.85 |
| CHEMBL5416112 | — | — | 1 | 4.84 |
| CHEMBL5413233 | — | — | 1 | 4.81 |
| CHEMBL5403104 | — | — | 1 | 4.81 |
| CHEMBL5429075 | — | — | 1 | 4.80 |
| CHEMBL5416438 | — | — | 1 | 4.80 |
| CHEMBL5400608 | — | — | 1 | 4.79 |
| CHEMBL5415370 | — | — | 1 | 4.74 |
| CHEMBL5409557 | — | — | 1 | 4.73 |
| CHEMBL5429437 | — | — | 1 | 4.71 |
| CHEMBL5430638 | — | — | 1 | 4.60 |
| CHEMBL5406011 | — | — | 1 | 4.59 |
| CHEMBL5410356 | — | — | 1 | 4.57 |
| CHEMBL5427040 | — | — | 1 | 4.54 |
| CHEMBL5425157 | — | — | 1 | 4.53 |
| CHEMBL5411573 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436184 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5410723 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5405637 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5438468 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5423005 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5400628 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5432068 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5412542 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5430385 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5408811 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5432750 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5432952 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5406520 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5428451 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL5441042 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5416112 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5413233 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5403104 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL5429075 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5416438 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5400608 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5415370 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL5409557 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5429437 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5430638 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL5406011 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL5410356 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL5427040 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL5425157 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5411573 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL5400171 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL5429507 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL5402890 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL5405668 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL5424985 | — | IC50 | = | 66400.0 | nM | 4.18 |
| CHEMBL420815 | — | IC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL5430454 | — | IC50 | = | 73800.0 | nM | 4.13 |
| CHEMBL5421922 | — | IC50 | = | 75200.0 | nM | 4.12 |
| CHEMBL5405891 | — | IC50 | = | 78200.0 | nM | 4.11 |
| CHEMBL5439215 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL5409690 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424654 | — | IC50 | > | 100000.0 | nM | - |