Assay Detail
Functional
CHEMBL5388452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of multi-drug resistance in human A2780/Taxol cells incubated for 48 hrs by MTT assay
52
Total Activities
51
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780/Taxol |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.86 | 8.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407291 | — | — | 2 | 8.00 |
| CHEMBL5410711 | — | — | 1 | 7.70 |
| CHEMBL5436649 | — | — | 1 | 7.68 |
| CHEMBL5437478 | — | — | 1 | 7.54 |
| CHEMBL5412603 | — | — | 1 | 7.54 |
| CHEMBL5435705 | — | — | 1 | 7.51 |
| CHEMBL5397690 | — | — | 1 | 7.51 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.50 |
| CHEMBL5424860 | — | — | 1 | 7.44 |
| CHEMBL5394596 | — | — | 1 | 7.37 |
| CHEMBL5405987 | — | — | 1 | 7.28 |
| CHEMBL5406723 | — | — | 1 | 7.26 |
| CHEMBL5423761 | — | — | 1 | 7.21 |
| CHEMBL5420970 | — | — | 1 | 7.17 |
| CHEMBL5432558 | — | — | 1 | 7.16 |
| CHEMBL5435183 | — | — | 1 | 7.16 |
| CHEMBL5416488 | — | — | 1 | 7.14 |
| CHEMBL5427216 | — | — | 1 | 7.14 |
| CHEMBL5411123 | — | — | 1 | 7.12 |
| CHEMBL5403876 | — | — | 1 | 7.07 |
| CHEMBL5432882 | — | — | 1 | 7.07 |
| CHEMBL5435472 | — | — | 1 | 7.07 |
| CHEMBL5401477 | — | — | 1 | 7.06 |
| CHEMBL5396539 | — | — | 1 | 7.06 |
| CHEMBL5411745 | — | — | 1 | 7.03 |
| CHEMBL5416108 | — | — | 1 | 7.03 |
| CHEMBL5424194 | — | — | 1 | 6.97 |
| CHEMBL5441110 | — | — | 1 | 6.84 |
| CHEMBL5401742 | — | — | 1 | 6.72 |
| CHEMBL5407815 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407291 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5410711 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5436649 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5412603 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5437478 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5435705 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5397690 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5424860 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5394596 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5405987 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5406723 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5423761 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5420970 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5432558 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5435183 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5427216 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5416488 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5411123 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5432882 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5403876 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5435472 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5401477 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5396539 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5411745 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5416108 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5424194 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5441110 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL5401742 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL5407815 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5431634 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL5420713 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5397922 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5439712 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5418480 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5396434 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5409240 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5418372 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL5430472 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL5421322 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL5432390 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL5408320 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL5439195 | — | IC50 | = | 1578.0 | nM | 5.80 |
| CHEMBL5422212 | — | IC50 | = | 1591.0 | nM | 5.80 |
| CHEMBL5439959 | — | IC50 | = | 2762.0 | nM | 5.56 |
| CHEMBL5393762 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL5398578 | — | IC50 | - | — | - | |
| CHEMBL5427756 | — | IC50 | - | — | - | |
| CHEMBL5415389 | — | IC50 | - | — | - |