Assay Detail
Functional
CHEMBL5388964
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Antiproliferative activity against human A2780AD cells overexpressing P-gp assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780AD |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.39 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437532 | — | — | 1 | 8.49 |
| CHEMBL292702 | MAYTANSINE | 2.0 | 1 | 7.72 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.70 |
| CHEMBL5418923 | — | — | 1 | 7.27 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.16 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 6.96 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437532 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL292702 | MAYTANSINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL61 | PODOFILOX | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5418923 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 392.0 | nM | 6.41 |