Assay Detail
Functional
CHEMBL5388966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.74 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292702 | MAYTANSINE | 2.0 | 1 | 9.48 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.27 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 9.15 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL5437532 | — | — | 1 | 8.80 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.81 |
| CHEMBL5418923 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292702 | MAYTANSINE | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5437532 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL61 | PODOFILOX | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5418923 | — | IC50 | = | 19.0 | nM | 7.72 |