Assay Detail
Functional
CHEMBL5388971
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Antiproliferative activity against human A2780AD cells overexpressing P-gp assessed as inhibition of cell growth
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780AD |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.84 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410715 | — | — | 1 | 7.41 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410715 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL107 | COLCHICINE | IC50 | = | 537.0 | nM | 6.27 |