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Assay Detail

CHEMBL5389189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplatelet activity in human platelets assessed as inhibition of U46619-induced platelet aggregation by turbidimetric analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Platelet
Confidence 1 — Organism
Curated By Autocuration

Target

Platelet (CHEMBL4296519)
Type CELL-LINE

Publication

Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition.
Juang YP, Tsai JY, Gu WL, Hsu HC, Lin CL, Wu CC, Liang PH.
J Med Chem (2024) 67 : 3626 -3642
PubMed 38381886 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.61 6.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5399770 1 6.02
CHEMBL5425232 1 5.89
CHEMBL3604102 1 5.87
CHEMBL5404518 1 5.86
CHEMBL5410443 1 5.82
CHEMBL5418475 1 5.81
CHEMBL5431799 1 5.80
CHEMBL5425426 1 5.75
CHEMBL5418352 1 5.74
CHEMBL5412369 1 5.73
CHEMBL5395973 1 5.73
CHEMBL5405902 1 5.61
CHEMBL5417462 1 5.58
CHEMBL5408166 1 5.45
CHEMBL43612 JUGLONE 1 5.35
CHEMBL5423893 1 5.34
CHEMBL5403732 1 5.20
CHEMBL5434284 1 5.15
CHEMBL5424541 1 4.86
CHEMBL44308 1 -
CHEMBL493651 1 -
CHEMBL1089486 1 -
CHEMBL5438783 1 -
CHEMBL453728 1 -
CHEMBL5402937 1 -
CHEMBL25 ASPIRIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5399770 IC50 = 950.0 nM 6.02
CHEMBL5425232 IC50 = 1300.0 nM 5.89
CHEMBL3604102 IC50 = 1350.0 nM 5.87
CHEMBL5404518 IC50 = 1370.0 nM 5.86
CHEMBL5410443 IC50 = 1520.0 nM 5.82
CHEMBL5418475 IC50 = 1540.0 nM 5.81
CHEMBL5431799 IC50 = 1600.0 nM 5.80
CHEMBL5425426 IC50 = 1760.0 nM 5.75
CHEMBL5418352 IC50 = 1820.0 nM 5.74
CHEMBL5412369 IC50 = 1880.0 nM 5.73
CHEMBL5395973 IC50 = 1850.0 nM 5.73
CHEMBL5405902 IC50 = 2430.0 nM 5.61
CHEMBL5417462 IC50 = 2660.0 nM 5.58
CHEMBL5408166 IC50 = 3540.0 nM 5.45
CHEMBL43612 JUGLONE IC50 = 4450.0 nM 5.35
CHEMBL5423893 IC50 = 4610.0 nM 5.34
CHEMBL5403732 IC50 = 6320.0 nM 5.20
CHEMBL5434284 IC50 = 7130.0 nM 5.15
CHEMBL5424541 IC50 = 13680.0 nM 4.86
CHEMBL44308 IC50 > 20000.0 nM -
CHEMBL493651 IC50 > 20000.0 nM -
CHEMBL1089486 IC50 > 20000.0 nM -
CHEMBL5438783 IC50 > 20000.0 nM -
CHEMBL453728 IC50 > 20000.0 nM -
CHEMBL5402937 IC50 > 50000.0 nM -
CHEMBL25 ASPIRIN IC50 > 200000.0 nM -