Assay Detail
Binding
CHEMBL5389221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ERp57 assessed as inhibition of E-GSH formation using Di-E-GSSG as substrate measured for 60 mins in presence of DTT by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.42 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43612 | JUGLONE | — | 1 | 5.62 |
| CHEMBL5418475 | — | — | 1 | 5.49 |
| CHEMBL5399770 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43612 | JUGLONE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5418475 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL5399770 | — | IC50 | = | 6980.0 | nM | 5.16 |