Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5389268

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against choloroquine-sensitive ring stage of Plasmodium falciparum 3D7 assessed as inhibition of parasite growth measured after 72 hrs by DAPI staining based analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Chemical and Antiplasmodial Investigations on <i>Eremophila</i>-Derived Alkaloids and Semisynthetic Ether Analogues.
Zhang C, Lum KY, White JM, Duffy S, Lock AM, Avery VM, Davis RA.
J Nat Prod (2024) 87 : 849 -854
PubMed 38416027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.64 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 7.96
CHEMBL307261 ARTENIMOL 3.0 1 7.68
CHEMBL469912 PUROMYCIN 2.0 1 7.48
CHEMBL5417741 1 5.14
CHEMBL5401464 1 5.12
CHEMBL5427002 1 5.10
CHEMBL5404985 1 5.10
CHEMBL4278900 1 5.05
CHEMBL5414075 1 5.01
CHEMBL5410453 1 4.96
CHEMBL5424190 1 4.90
CHEMBL5403877 1 4.88
CHEMBL5403713 1 4.88
CHEMBL36 PYRIMETHAMINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 11.0 nM 7.96
CHEMBL307261 ARTENIMOL IC50 = 21.0 nM 7.68
CHEMBL469912 PUROMYCIN IC50 = 33.0 nM 7.48
CHEMBL5417741 IC50 = 7200.0 nM 5.14
CHEMBL5401464 IC50 = 7600.0 nM 5.12
CHEMBL5427002 IC50 = 8000.0 nM 5.10
CHEMBL5404985 IC50 = 8000.0 nM 5.10
CHEMBL4278900 IC50 = 8900.0 nM 5.05
CHEMBL5414075 IC50 = 9700.0 nM 5.01
CHEMBL5410453 IC50 = 11000.0 nM 4.96
CHEMBL5424190 IC50 = 12500.0 nM 4.90
CHEMBL5403877 IC50 = 13100.0 nM 4.88
CHEMBL5403713 IC50 = 13100.0 nM 4.88
CHEMBL36 PYRIMETHAMINE IC50 = - nM -