Assay Detail
Binding
CHEMBL5389734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse TRPM7 transfected in HEK293T cells assessed as inhibition of channel current in absence of intracellular Mg2+ by whole cell patch clamp analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 7 (CHEMBL3714706) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral <i>Sarcothelia edmondsoni</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.96 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470334 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470334 | — | IC50 | = | 110.0 | nM | 6.96 |