Assay Detail
Binding
CHEMBL5389737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLAG-tagged mouse TRPM7 transfected in HEK293 cells assessed as inhibition of channel-mediated Mn2+ influx incubated for ~15 mins and measured for 90 secs by Fura-2-dye based fluorescence analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 7 (CHEMBL3714706) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral <i>Sarcothelia edmondsoni</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.73 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423236 | — | — | 1 | 4.92 |
| CHEMBL5400468 | — | — | 1 | 4.89 |
| CHEMBL5416180 | — | — | 1 | 4.70 |
| CHEMBL5399993 | — | — | 1 | 4.70 |
| CHEMBL169233 | — | — | 1 | 4.66 |
| CHEMBL5420149 | — | — | 1 | 4.48 |
| CHEMBL5426001 | — | — | 1 | - |
| CHEMBL5408631 | — | — | 1 | - |
| CHEMBL5436076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423236 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5400468 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5416180 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5399993 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL169233 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5420149 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5426001 | — | IC50 | > | 130000.0 | nM | - |
| CHEMBL5408631 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5436076 | — | IC50 | > | 150000.0 | nM | - |