Assay Detail
Binding
CHEMBL5389738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPM7 transfected in Tet-inducible HEK293-T-REx cells assessed as inhibition of channel current in presence of 780 uM intracellular Mg2+ by whole cell patch clamp analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-T-REx |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 7 (CHEMBL1250412) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral <i>Sarcothelia edmondsoni</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.05 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423236 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423236 | — | IC50 | = | 90.0 | nM | 7.05 |