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Assay Detail

CHEMBL5389999

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, <i>in vitro</i> and <i>in silico</i> evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents.
Kaur K, Verma H, Gangwar P, Dhiman M, Jaitak V.
RSC Med Chem (2024) 15 : 1329 -1347
PubMed 38665833 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.95 5.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5403677 1 5.51
CHEMBL46740 BAZEDOXIFENE 4.0 1 5.14
CHEMBL5409715 1 5.11
CHEMBL5430117 1 5.10
CHEMBL5410125 1 5.08
CHEMBL5433762 1 5.06
CHEMBL5434102 1 5.03
CHEMBL5394816 1 5.00
CHEMBL5410998 1 5.00
CHEMBL5417920 1 4.99
CHEMBL5397893 1 4.95
CHEMBL5396889 1 4.92
CHEMBL5422689 1 4.90
CHEMBL5429079 1 4.88
CHEMBL5429759 1 4.88
CHEMBL5419542 1 4.85
CHEMBL5417013 1 4.83
CHEMBL5402115 1 4.82
CHEMBL5427283 1 4.79
CHEMBL5436969 1 4.78
CHEMBL5415998 1 4.69
CHEMBL5433840 1 4.64
CHEMBL5425196 1 -
CHEMBL5401411 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5403677 IC50 = 3080.0 nM 5.51
CHEMBL46740 BAZEDOXIFENE IC50 = 7310.0 nM 5.14
CHEMBL5409715 IC50 = 7830.0 nM 5.11
CHEMBL5430117 IC50 = 7950.0 nM 5.10
CHEMBL5410125 IC50 = 8320.0 nM 5.08
CHEMBL5433762 IC50 = 8730.0 nM 5.06
CHEMBL5434102 IC50 = 9240.0 nM 5.03
CHEMBL5394816 IC50 = 9990.0 nM 5.00
CHEMBL5410998 IC50 = 9930.0 nM 5.00
CHEMBL5417920 IC50 = 10210.0 nM 4.99
CHEMBL5397893 IC50 = 11270.0 nM 4.95
CHEMBL5396889 IC50 = 11890.0 nM 4.92
CHEMBL5422689 IC50 = 12700.0 nM 4.90
CHEMBL5429079 IC50 = 13170.0 nM 4.88
CHEMBL5429759 IC50 = 13290.0 nM 4.88
CHEMBL5419542 IC50 = 14220.0 nM 4.85
CHEMBL5417013 IC50 = 14790.0 nM 4.83
CHEMBL5402115 IC50 = 15070.0 nM 4.82
CHEMBL5427283 IC50 = 16370.0 nM 4.79
CHEMBL5436969 IC50 = 16650.0 nM 4.78
CHEMBL5415998 IC50 = 20630.0 nM 4.69
CHEMBL5433840 IC50 = 22650.0 nM 4.64
CHEMBL5425196 IC50 > 25000.0 nM -
CHEMBL5401411 IC50 > 25000.0 nM -