Assay Detail
Binding
CHEMBL5390754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic elastase using N-succinyl-Ala-Ala-Ala-p-nitroanilide as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured for 30 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cyclotheonellazoles D-I, Potent Elastase Inhibitory Thiazole-Containing Cyclic Peptides from <i>Theonella</i> sp. (2131).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.45 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431486 | — | — | 1 | 7.80 |
| CHEMBL5432223 | — | — | 1 | 7.75 |
| CHEMBL5418049 | — | — | 1 | 7.70 |
| CHEMBL5394627 | — | — | 1 | 7.55 |
| CHEMBL5408836 | — | — | 1 | 7.46 |
| CHEMBL5414337 | — | — | 1 | 7.29 |
| CHEMBL5397807 | — | — | 1 | 7.21 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431486 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5432223 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL5418049 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL5394627 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5408836 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL5414337 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL5397807 | — | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 138.1 | nM | 6.86 |