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Assay Detail

CHEMBL5390959

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL-28
Confidence 1 — Organism
Curated By Autocuration

Target

SK-MEL-28 (CHEMBL614919)
Type CELL-LINE
Organism Homo sapiens

Publication

Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies.
Laxmikeshav K, Rahman Z, Mahale A, Gurukkala Valapil D, Sharma P, George J, Phanindranath R, Dandekar MP, Kulkarni OP, Nagesh N, Shankaraiah N.
Bioorg Med Chem Lett (2023) 96 : 129494 -129494
PubMed 37797804 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.29 5.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5421641 1 5.59
CHEMBL5396880 1 5.57
CHEMBL5426967 1 5.53
CHEMBL5421497 1 5.48
CHEMBL5416712 1 5.42
CHEMBL5436235 1 5.27
CHEMBL5407996 1 5.21
CHEMBL5416890 1 5.11
CHEMBL5426589 1 5.07
CHEMBL9514 NOCODAZOLE 2.0 1 5.07
CHEMBL5428691 1 4.92
CHEMBL5415700 1 -
CHEMBL5426734 1 -
CHEMBL5423621 1 -
CHEMBL5424628 1 -
CHEMBL5414578 1 -
CHEMBL5402587 1 -
CHEMBL5428257 1 -
CHEMBL5415467 1 -
CHEMBL5403705 1 -
CHEMBL5414436 1 -
CHEMBL5433103 1 -
CHEMBL5421877 1 -
CHEMBL5416903 1 -
CHEMBL5409096 1 -
CHEMBL5434372 1 -
CHEMBL5411278 1 -
CHEMBL5415541 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5421641 IC50 = 2550.0 nM 5.59
CHEMBL5396880 IC50 = 2690.0 nM 5.57
CHEMBL5426967 IC50 = 2950.0 nM 5.53
CHEMBL5421497 IC50 = 3320.0 nM 5.48
CHEMBL5416712 IC50 = 3820.0 nM 5.42
CHEMBL5436235 IC50 = 5420.0 nM 5.27
CHEMBL5407996 IC50 = 6130.0 nM 5.21
CHEMBL5416890 IC50 = 7710.0 nM 5.11
CHEMBL5426589 IC50 = 8590.0 nM 5.07
CHEMBL9514 NOCODAZOLE IC50 = 8590.0 nM 5.07
CHEMBL5428691 IC50 = 12160.0 nM 4.92
CHEMBL5415700 IC50 > 20000.0 nM -
CHEMBL5426734 IC50 > 20000.0 nM -
CHEMBL5423621 IC50 > 20000.0 nM -
CHEMBL5424628 IC50 > 20000.0 nM -
CHEMBL5414578 IC50 > 20000.0 nM -
CHEMBL5402587 IC50 > 20000.0 nM -
CHEMBL5428257 IC50 > 20000.0 nM -
CHEMBL5415467 IC50 > 20000.0 nM -
CHEMBL5403705 IC50 > 20000.0 nM -
CHEMBL5414436 IC50 > 20000.0 nM -
CHEMBL5433103 IC50 > 20000.0 nM -
CHEMBL5421877 IC50 > 20000.0 nM -
CHEMBL5416903 IC50 > 20000.0 nM -
CHEMBL5409096 IC50 > 20000.0 nM -
CHEMBL5434372 IC50 > 20000.0 nM -
CHEMBL5411278 IC50 > 20000.0 nM -
CHEMBL5415541 IC50 > 20000.0 nM -