Assay Detail
Binding
CHEMBL5392121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by ATP addition measured after 18 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL1741208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.56 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419955 | — | — | 1 | 10.15 |
| CHEMBL5404792 | — | — | 1 | 8.36 |
| CHEMBL5431968 | — | — | 1 | 8.27 |
| CHEMBL5402007 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419955 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5404792 | — | IC50 | = | 4.34 | nM | 8.36 |
| CHEMBL5431968 | — | IC50 | = | 5.32 | nM | 8.27 |
| CHEMBL5402007 | — | IC50 | = | 36.5 | nM | 7.44 |