Assay Detail
Binding
CHEMBL5392132
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 (unknown origin) assessed as reduction of IL-1beta production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL1741208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.35 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188223 | — | — | 1 | 5.49 |
| CHEMBL4277456 | — | — | 1 | 5.49 |
| CHEMBL4583133 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188223 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4277456 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4583133 | — | IC50 | = | 8450.0 | nM | 5.07 |