Assay Detail
Binding
CHEMBL5392238
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at human Nurr1 LBD transiently transfected in HEK293T cells incubated for 16 hrs by Gal4-hybrid reporter gene based Dual-glo luciferase assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL5002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring Fatty Acid Mimetics as NR4A Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.42 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397040 | — | — | 1 | 4.43 |
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 4.40 |
| CHEMBL5401203 | — | — | 1 | - |
| CHEMBL271207 | — | — | 1 | - |
| CHEMBL81936 | — | — | 1 | - |
| CHEMBL5424412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397040 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1071 | OXAPROZIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5401203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL271207 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL81936 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5424412 | — | IC50 | > | 100000.0 | nM | - |