Assay Detail
Binding
CHEMBL5392245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal 6His-tagged Nurr1 LBD (362 to 598 residues) (unknown origin) expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells assessed as dissociation constant at 100 uM by ITC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL5002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring Fatty Acid Mimetics as NR4A Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.41 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427562 | — | — | 1 | 6.77 |
| CHEMBL5405485 | — | — | 1 | 6.75 |
| CHEMBL5440658 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427562 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL5405485 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL5440658 | — | Kd | = | 2000.0 | nM | 5.70 |