Assay Detail
Functional
CHEMBL5392480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H3255 cells harboring EGFR L858R mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo luminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H3255 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.67 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394686 | — | — | 1 | 8.14 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.96 |
| CHEMBL5420585 | — | — | 1 | 7.77 |
| CHEMBL5430456 | — | — | 1 | 7.43 |
| CHEMBL5430101 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394686 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL939 | GEFITINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5420585 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5430456 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5430101 | — | IC50 | = | 88.0 | nM | 7.06 |