Assay Detail
Toxicity
CHEMBL5393050
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Agonist activity at Niacin receptor (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal <i>in Vivo</i> Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.96 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589586 | MONOMETHYL FUMARATE | 4.0 | 1 | 9.02 |
| CHEMBL2107333 | DIMETHYL FUMARATE | 4.0 | 1 | 6.89 |
| CHEMBL5415198 | — | — | 1 | - |
| CHEMBL5393772 | — | — | 1 | - |
| CHEMBL5408914 | — | — | 1 | - |
| CHEMBL5430762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589586 | MONOMETHYL FUMARATE | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL2107333 | DIMETHYL FUMARATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5415198 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5393772 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5408914 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5430762 | — | IC50 | > | 1000.0 | nM | - |