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Assay Detail

CHEMBL5393202

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Plasmodium falciparum ARK3 incubated for 2 hrs by luciferin-reagent based luminometer analysis
20
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Characterization of 2,4-Dianilinopyrimidines Against Five <i>P. falciparum</i> Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB.
Ong HW, de Silva C, Avalani K, Kwarcinski F, Mansfield CR, Chirgwin M, Truong A, Derbyshire ER, Zutshi R, Drewry DH.
ACS Med Chem Lett (2023) 14 : 1774 -1784
PubMed 38116430 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.54 6.48
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5404158 1 6.48
CHEMBL5438382 1 6.36
CHEMBL5406220 1 6.34
CHEMBL5401827 1 6.00
CHEMBL5401797 1 5.96
CHEMBL5437763 1 5.92
CHEMBL5430022 1 5.85
CHEMBL5403415 1 5.85
CHEMBL4303382 2 5.75
CHEMBL5408698 1 5.70
CHEMBL5417334 1 5.22
CHEMBL5405833 1 5.16
CHEMBL5399438 1 5.16
CHEMBL5429615 1 5.16
CHEMBL5405676 1 5.10
CHEMBL5425074 1 5.10
CHEMBL5408005 1 4.96
CHEMBL5435721 1 4.85
CHEMBL5397036 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5404158 IC50 = 330.0 nM 6.48
CHEMBL5438382 IC50 = 440.0 nM 6.36
CHEMBL5406220 IC50 = 460.0 nM 6.34
CHEMBL5401827 IC50 = 1000.0 nM 6.00
CHEMBL5401797 IC50 = 1100.0 nM 5.96
CHEMBL5437763 IC50 = 1200.0 nM 5.92
CHEMBL5430022 IC50 = 1400.0 nM 5.85
CHEMBL5403415 IC50 = 1400.0 nM 5.85
CHEMBL4303382 IC50 = 1800.0 nM 5.75
CHEMBL5408698 IC50 = 2000.0 nM 5.70
CHEMBL5417334 IC50 = 6000.0 nM 5.22
CHEMBL5429615 IC50 = 7000.0 nM 5.16
CHEMBL5405833 IC50 = 7000.0 nM 5.16
CHEMBL5399438 IC50 = 7000.0 nM 5.16
CHEMBL5425074 IC50 = 8000.0 nM 5.10
CHEMBL5405676 IC50 = 8000.0 nM 5.10
CHEMBL5408005 IC50 = 11000.0 nM 4.96
CHEMBL5435721 IC50 = 14000.0 nM 4.85
CHEMBL5397036 IC50 = 49000.0 nM 4.31
CHEMBL4303382 Activity - -