Assay Detail
Binding
CHEMBL5393203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum NEK3 incubated for 2 hrs by luciferin-reagent based luminometer analysis
27
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Characterization of 2,4-Dianilinopyrimidines Against Five <i>P. falciparum</i> Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.30 | 7.31 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425074 | — | — | 1 | 7.31 |
| CHEMBL5429615 | — | — | 1 | 7.24 |
| CHEMBL5417334 | — | — | 1 | 7.22 |
| CHEMBL5408698 | — | — | 1 | 6.96 |
| CHEMBL5435721 | — | — | 1 | 6.92 |
| CHEMBL5411844 | — | — | 1 | 6.85 |
| CHEMBL5408005 | — | — | 1 | 6.66 |
| CHEMBL5405833 | — | — | 1 | 6.54 |
| CHEMBL5438382 | — | — | 1 | 6.44 |
| CHEMBL5437763 | — | — | 1 | 6.39 |
| CHEMBL5405676 | — | — | 1 | 6.38 |
| CHEMBL5401827 | — | — | 1 | 6.36 |
| CHEMBL5430022 | — | — | 1 | 6.29 |
| CHEMBL5399438 | — | — | 1 | 6.26 |
| CHEMBL5409587 | — | — | 1 | 6.22 |
| CHEMBL5406220 | — | — | 1 | 6.08 |
| CHEMBL5437259 | — | — | 1 | 6.05 |
| CHEMBL4303382 | — | — | 2 | 6.00 |
| CHEMBL5440041 | — | — | 1 | 5.92 |
| CHEMBL5404158 | — | — | 1 | 5.85 |
| CHEMBL5432474 | — | — | 1 | 5.85 |
| CHEMBL5399330 | — | — | 1 | 5.75 |
| CHEMBL5397036 | — | — | 1 | 5.70 |
| CHEMBL5436061 | — | — | 1 | 5.64 |
| CHEMBL5410378 | — | — | 1 | 5.60 |
| CHEMBL5401797 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425074 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5429615 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5417334 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5408698 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5435721 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5411844 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5408005 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5405833 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5438382 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5437763 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5405676 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5401827 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5430022 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5399438 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5409587 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5406220 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5437259 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4303382 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5440041 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5404158 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5432474 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5399330 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5397036 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5436061 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5410378 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5401797 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4303382 | — | Activity | - | — | - |