Assay Detail
Functional
CHEMBL5393235
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Antiproliferative activity against human KB cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Blue cell viability assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.28 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398059 | — | — | 1 | 8.46 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 8.00 |
| CHEMBL5433810 | — | — | 1 | 7.54 |
| CHEMBL374172 | — | — | 1 | 7.30 |
| CHEMBL5417031 | — | — | 1 | 7.30 |
| CHEMBL5416929 | — | — | 1 | 7.11 |
| CHEMBL5404618 | — | — | 1 | 6.46 |
| CHEMBL3407519 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398059 | — | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 9.95 | nM | 8.00 |
| CHEMBL5433810 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL374172 | — | IC50 | = | 49.49 | nM | 7.30 |
| CHEMBL5417031 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL5416929 | — | IC50 | = | 77.31 | nM | 7.11 |
| CHEMBL5404618 | — | IC50 | = | 347.37 | nM | 6.46 |
| CHEMBL3407519 | — | IC50 | = | 833.0 | nM | 6.08 |