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Assay Detail

CHEMBL5393271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Inhibition of recombinant MAO-B (unknown origin) using benzylamine as a substrate by MAO assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Repurposing Azoles to Resolve Serotogenic Toxicity Associated with Linezolid to Combat Multidrug-Resistant Tuberculosis.
Girase RT, Ahmad I, Oh JM, Kim H, Mathew B, Vagolu SK, Tønjum T, Desai NC, Sriram D, Kumari J, Patel HM.
ACS Med Chem Lett (2023) 14 : 1754 -1759
PubMed 38116435 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.20 6.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL126 LINEZOLID 4.0 1 6.21
CHEMBL91 MICONAZOLE 4.0 1 4.88
CHEMBL104 CLOTRIMAZOLE 4.0 1 4.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL126 LINEZOLID IC50 = 619.0 nM 6.21
CHEMBL91 MICONAZOLE IC50 = 13151.0 nM 4.88
CHEMBL104 CLOTRIMAZOLE IC50 = 31172.0 nM 4.51